Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Mar 14;14(10):1510-3.
doi: 10.3748/wjg.14.1510.

Hepatitis B virus genotypes in southwest Iran: molecular, serological and clinical outcomes

Anahita Mojiri  1 , Abbas Behzad-Behbahani, Mehdei Saberifirozi, Maryam Ardabili, Mahmood Beheshti, Marjan Rahsaz, Mehrdad Banihashemi, Negar Azarpira, Bita Geramizadeh, Baharak Khadang, Afsaneh Moaddeb, Mojgan Ghaedi, Tahereh Heidari, Ardeshir Torab, Alireza Salah, Saeid Amirzadeh, Zahra Jowkar, Davood Mehrabani, Samad Amini-Bavil-Olyaee, Mohammad-Ali Dehyadegari
Affiliations

Hepatitis B virus genotypes in southwest Iran: molecular, serological and clinical outcomes

Anahita Mojiri et al. World J Gastroenterol. .

Abstract

Aim: To investigate the associations of hepatitis B virus (HBV) genotype with HBeAg and anti-HBe status, alanine aminotransferase (ALT) levels and HBV-DNA detection in different groups of HBV-infected patients in southwest Iran.

Methods: A total of 89 HBsAg-positive serum samples were collected from the same number of patients. All sera were then investigated to determine HBV DNA and serological markers. For all the polymerase chain reaction (PCR)-positive samples, biochemical, histopathological assays and genotyping were also performed.

Results: Genotype D was the only type of HBV found in different clinical forms of acute and chronic infections. There was a high prevalence of HBeAg-negative HBV-infected patients with chronic hepatitis (52.7%). Out of 55 patients with chronic hepatitis, seven (12.7%) were diagnosed with cirrhosis. A significant association between the presence of anti-HBe antibody and an increase in ALT level, among either HBeAg-negative (P = 0.01) or HBeAg-positive (P = 0.026) patients, was demonstrated. No significant differences were observed between the clinical outcomes of HBeAg-positive and -negative individuals (P = 0.24).

Conclusion: Genotype D has been recognized as the only type of HBV found in different clinical forms of HBV infections, including cirrhosis, among the residents of southwest Iran. Anti-HBe possibly plays a role in disease progression in some patients with chronic hepatitis, at least for a period of disease.

PubMed Disclaimer

References

    1. Lau JY, Wright TL. Molecular virology and pathogenesis of hepatitis B. Lancet. 1993;342:1335–1340. - PubMed
    1. Kao JH, Chen PJ, Lai MY, Chen DS. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology. 2000;118:554–559. - PubMed
    1. Orito E, Ichida T, Sakugawa H, Sata M, Horiike N, Hino K, Okita K, Okanoue T, Iino S, Tanaka E, et al. Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan. Hepatology. 2001;34:590–594. - PubMed
    1. Kao JH, Chen PJ, Lai MY, Chen DS. Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers. J Med Virol. 2004;72:363–369. - PubMed
    1. Nakayoshi T, Maeshiro T, Nakayoshi T, Nakasone H, Sakugawa H, Kinjo F, Orito E, Mizokami M. Difference in prognosis between patients infected with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands: a prospective study. J Med Virol. 2003;70:350–354. - PubMed