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. 2008 May;71(5):856-60.
doi: 10.1021/np0705054. Epub 2008 Mar 11.

The berkeleyamides, amides from the acid lake fungus Penicillum rubrum

Andrea A Stierle  1 , Donald B Stierle, Brianna Patacini
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The berkeleyamides, amides from the acid lake fungus Penicillum rubrum

Andrea A Stierle et al. J Nat Prod. 2008 May.

Abstract

We previously reported several novel bioactive hybrid polyketide-terpenoid metabolites from a deep water Penicillium rubrum isolated from Berkeley Pit Lake, Butte, Montana. In this paper we report the structures of four new amides, berkeleyamides A-D (1, 4, 5, 7), isolated from extracts of this fungus. The structures of these compounds were deduced by analysis of NMR data, chemical derivatization, and comparison of their spectroscopic data to those of known compounds.

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