Yorkie and Scalloped: partners in growth activation
- PMID: 18331708
- DOI: 10.1016/j.devcel.2008.02.010
Yorkie and Scalloped: partners in growth activation
Abstract
The Hippo (Hpo) signaling pathway limits organ growth in organisms from Drosophila to mammals by suppressing the activity of the transcriptional coactivator Yorkie (Yki)/YAP. The TEAD/TEF factor Scalloped (Sd) has been identified as the first known transcription factor to partner with Yki as a downstream target of Hpo signaling.
Comment on
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The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.Dev Cell. 2008 Mar;14(3):377-87. doi: 10.1016/j.devcel.2008.01.006. Epub 2008 Feb 7. Dev Cell. 2008. PMID: 18258485 Free PMC article.
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The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.Dev Cell. 2008 Mar;14(3):388-98. doi: 10.1016/j.devcel.2008.01.007. Epub 2008 Feb 7. Dev Cell. 2008. PMID: 18258486
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