sSgo1, a guardian of centriole cohesion
- PMID: 18331711
- DOI: 10.1016/j.devcel.2008.02.008
sSgo1, a guardian of centriole cohesion
Abstract
Sgo1 plays a key role in protecting sister chromatid cohesion during mitosis. In this issue of Developmental Cell, Wang et al. describe a shorter splice variant of Sgo1 (sSgo1) that functions specifically in centriole cohesion. sSgo1 may be the "glue" that holds paired centrioles together in an engaged state before their disengagement in late mitosis.
Comment on
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sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1.Dev Cell. 2008 Mar;14(3):331-41. doi: 10.1016/j.devcel.2007.12.007. Dev Cell. 2008. PMID: 18331714 Free PMC article.
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