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. 2006;8(5):352-64.
doi: 10.1080/13651820600804146.

Adjuvant treatment

Asma Sultana  1 , John Neoptolemos, Paula Ghaneh
Affiliations

Adjuvant treatment

Asma Sultana et al. HPB (Oxford). 2006.

Abstract

Exocrine pancreatic cancer (pancreatic ductal adenocarcinoma) is one of the leading causes of cancer deaths in the western world, accounting for 5% of all cancer-related deaths. Only a small percentage of patients with pancreatic cancer are able to undergo potentially curative resection, even in specialized centres, and prognosis remains poor after successful surgery. Over the last few years efforts have been directed towards the development of adjuvant therapies in attempts to improve outcome. The main trials of adjuvant chemotherapy, chemoradiotherapy and chemoradiotherapy with follow-on chemotherapy are described in this paper, followed by the results of the ESPAC-1 trial and the status of ESPAC-2 and -3 trials.

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Figures

Figure 1.
Figure 1.
Kaplan–Meir estimates of survival according to whether or not patients received chemoradiotherapy (A) or chemotherapy (B) in the ESPAC-1 trial final results. CRT, chemoradiotherapy; CT, chemotherapy.
See this image and copyright information in PMC

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