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. 2005;7(4):259-62.
doi: 10.1080/13651820500373010.

Surgical management of hilar cholangiocarcinoma: the Nagoya experience

Hideki Nishio  1 , Masato Nagino, Yuji Nimura
Affiliations

Surgical management of hilar cholangiocarcinoma: the Nagoya experience

Hideki Nishio et al. HPB (Oxford). 2005.

Abstract

Of 400 patients with hilar cholangiocarcinoma who were treated at Nagoya University Hospital from 1977 to 2004, 301 (75%) underwent surgical resection. Most patients underwent major hepatectomy with extrahepatic bile duct resection. The overall mortality rate was 7.6% but had decreased to 2.5% in the last 5 years (p=0.007). The overall survival rates at 5, 10 and 15 years were 22%, 13% and 10%, respectively. The survival rates of 233 patients undergoing R0 resection were 27%, 16% and 13%, respectively. R1 or R2 resection, lymph node metastasis and portal vein involvement were significant negative prognostic factors, although survival was better than in patients with unresected tumours. The results show that aggressive surgical treatment of hilar cholangiocarcinoma offers good outcomes with an acceptable mortality rate.

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Figures

Figure 1.
Figure 1.
Overall survival curves of patients who underwent resection for hilar cholangiocarcinoma (1977–2004). MST, median survival time.
Figure 2.
Figure 2.
Survival curves according to completeness of resection. R0, microscopically radical resection; R1, macroscopically radical resection; R2, macroscopically non-radical resection.
Figure 3.
Figure 3.
Survival curves according to the presence of lymph node metastasis (LNM).
Figure 4.
Figure 4.
Survival curves according to portal vein resection. PVR, portal vein resection and reconstruction.
See this image and copyright information in PMC

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