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. 2008 Mar 11;5(3):e67.
doi: 10.1371/journal.pmed.0050067.

Observational research, randomised trials, and two views of medical science

Jan P Vandenbroucke  1
Affiliations

Observational research, randomised trials, and two views of medical science

Jan P Vandenbroucke. PLoS Med. .

Abstract

Two views exist of medical science, says the author, one emphasizing discovery and explanation, the other emphasizing evaluation of interventions.

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Conflict of interest statement

Competing Interests: The author has declared that no competing interests exist.

Figures

Figure 1
Figure 1. Axis of Haphazardness of Exposure
Figure 2
Figure 2. Axis of Multiplicity
See this image and copyright information in PMC

References

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    1. Vandenbroucke JP, Koster T, Briet E, Reitsma PH, Bertina RM, et al. Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet. 1994;344:1453–1457. - PubMed
    1. Vandenbroucke JP, Rosendaal FR, Bertina RM. Factor V Leiden, oral contraceptives and deep vein thrombosis. In: Khoury JM, Little J, Burke W, editors. Human genome epidemiology. New York: Oxford University Press; 2004. pp. 322–332.
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    1. Vandenbroucke JP, Kroep JR. Bortezomib in multiple myeloma. N Engl J Med. 2005;353:1297–1298. - PubMed