Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Sep;33(8):867-74.
doi: 10.1093/jpepsy/jsn022. Epub 2008 Mar 11.

Medication adherence and quality of life in pediatric inflammatory bowel disease

Kevin A Hommel  1 , Christine M Davis, Robert N Baldassano
Affiliations

Medication adherence and quality of life in pediatric inflammatory bowel disease

Kevin A Hommel et al. J Pediatr Psychol. 2008 Sep.

Abstract

Objective: To examine the relationship between medication adherence and quality of life (QOL) in adolescent patients with inflammatory bowel disease (IBD) utilizing a multimethod adherence assessment approach.

Methods: Medication adherence in 36 adolescents with IBD was assessed via interviews, pill counts, and biological assays. QOL was assessed via patient and parent report. Pediatric gastroenterologists provided disease severity assessments.

Results: Hierarchical multiple regression analyses revealed that adherence contributed significant variance to patient-reported QOL but not parent-reported QOL. Nonadherence to 6-MP/azathioprine was related to poorer patient-reported physical health QOL. Greater self-reported 5-ASA adherence was related to poorer overall psychological health QOL, and particularly social functioning QOL.

Conclusions: Results provide preliminary support for the negative effects of 6-MP/azathioprine nonadherence on QOL and an inverse relationship between 5-ASA adherence and QOL in this population. Adherence burden in patients and the utility of multimethod adherence assessment in research are discussed.

PubMed Disclaimer

References

    1. Barakat LP, Lutz M, Smith-Whitley K, Ohene-Frempong K. Is treatment adherence associated with better quality of life in children with sickle cell disease? Quality of Life Research. 2005;14:407–414. - PubMed
    1. Belaiche J, Desager JP, Horsmans Y, Louis E. Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease. Scandinavian Journal of Gastroenterology. 2001;36:71–76. - PubMed
    1. Berg JS, Dischler J, Wagner DJ, Raia J, Palmer-Shevlin N. Medication compliance: A health care problem. The Annals of Pharmacotherapy. 1993;27(Suppl):2–21. - PubMed
    1. Crohn's and Colitis Foundation of America (CCFA) What is IBD: Race and ethnicity. 2008. Retrieved January 17, 2008, from http://ccfa.org/info/about/crohns.
    1. Cronbach L. Coefficient alpha and the internal structure of tests. Psychometrika. 1951;16:297–334.

Publication types

MeSH terms