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Case Reports
. 2008 Oct;10(5):495-500.
doi: 10.1016/j.jfms.2008.01.003. Epub 2008 Mar 12.

Presumed primary immune-mediated thrombocytopenia in four cats

Domenico Bianco  1 , P Jane Armstrong, Robert J Washabau
Affiliations
Case Reports

Presumed primary immune-mediated thrombocytopenia in four cats

Domenico Bianco et al. J Feline Med Surg. 2008 Oct.

Abstract

Feline primary immune-mediated thrombocytopenia (pIMT) is a rare hematological disorder. Platelet-bound antibody assays for cats have variable specificity and sensitivity and are not widely available. Diagnosis of pIMT is made on the basis of exclusion of other identifiable causes of thrombocytopenia and the response to immunosuppressive therapy. This report describes four cats with severe thrombocytopenia and no detectable underlying disease. One cat was euthanased because of pulmonary hemorrhage, while the other cats had frequent relapses, two of these cats developed diabetes mellitus due to long-term corticosteroid therapy. In these cats IMT had a chronic course and responded poorly to therapy with prednisolone. Alternative immunomodulatory drugs may be considered in the treatment of feline IMT.

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Figures

Fig 1.
Fig 1.
Moderate megakaryocytic hyperplasia in case 2.
Fig 2.
Fig 2.
Megakaryocyte with intracytoplasmatic neutrophil(emperipolesis) in case 3.
See this image and copyright information in PMC

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