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Comparative Study
. 1991 Aug;35(8):1677-8.
doi: 10.1128/AAC.35.8.1677.

Effect of pH on the in vitro potency of clarithromycin against Mycobacterium avium complex

C Truffot-Pernot  1 , B Ji, J Grosset
Affiliations
Comparative Study

Effect of pH on the in vitro potency of clarithromycin against Mycobacterium avium complex

C Truffot-Pernot et al. Antimicrob Agents Chemother. 1991 Aug.

Abstract

Employing 7H11 agar medium at pH 6.6, the MICs of clarithromycin for 50% (MIC50) and 90% (MIC90) of 19 strains of Mycobacterium avium complex were 8 and 16 micrograms/ml, respectively. However, the MICs were 2 to 3 log2 dilutions lower in the 7H11 medium adjusted to pH 7.4, and the MICs on 10% OADC (oleic acid-albumin-dextrose-catalase)-enriched Mueller-Hinton agar at pH 7.3 were also 2 log2 dilutions lower than those measured on 7H11 agar at pH 6.6. Therefore, clarithromycin is more active at a physiologic than at an acidic pH.

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References

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