doi: 10.1021/ol800256j.
Epub 2008 Mar 15.
Regio- and enantioselective catalytic cyclization of pyrroles onto N-acyliminium ions
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- PMID: 18341346
- DOI: 10.1021/ol800256j
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Regio- and enantioselective catalytic cyclization of pyrroles onto N-acyliminium ions
Org Lett.
.
Abstract
The regio- and enantioselective cyclization of pyrroles onto N-acyliminium ions generated in situ from hydroxylactams is reported. Modest to excellent ee's and yields are obtained in these novel Pictet-Spengler-type reactions with a chiral thiourea-pyrrole catalyst. Useful synthetic transformations of the versatile pyrroloindolizidinone and pyrroloquinolizidinone products are presented.
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