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Review
. 2008;7(3):8.
doi: 10.1186/jbiol70. Epub 2008 Mar 7.

A Caenorhabditis elegans genetic-interaction map wiggles into view

Kristin C Gunsalus  1
Affiliations
Review

A Caenorhabditis elegans genetic-interaction map wiggles into view

Kristin C Gunsalus. J Biol. 2008.

Abstract

Systematic mapping of genetic-interaction networks will provide an essential foundation for understanding complex genetic disorders, mechanisms of genetic buffering and principles of robustness and evolvability. A recent study of signaling pathways in Caenorhabditis elegans lays the next row of bricks in this foundation.

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Figures

Figure 1
Figure 1
Adapted from Byrne et al. [2], a superimposed network composed of different types of functional linkages contains subnetworks of genes that are highly interconnected based on one type of data: coexpression (blue), co-phenotype (green), or eukaryotic protein-protein interactions ('interolog'; purple). Byrne et al. found that these subnetworks were bridged by genetic interactions (pink) more often than expected by chance. Many such subnetworks were enriched for genes with shared functional annotations, supporting the idea that enhancing genetic interactions (identified by reduced function of a pair of genes) tend to bridge distinct functional modules.
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