Review
doi: 10.1016/j.immuni.2008.02.009.
Baseless assumptions: activation of TLR9 by DNA
Affiliations
- PMID: 18342000
- DOI: 10.1016/j.immuni.2008.02.009
Item in Clipboard
Review
Baseless assumptions: activation of TLR9 by DNA
Immunity.
2008 Mar.
Free article
Abstract
The Toll-like receptor 9 (TLR9) is activated by DNA presented in acidified, intracellular compartments. Previous studies suggested that signaling required unmethylated CpG dinucleotides, but in this issue of Immunity, Haas et al. (2008) challenge this view, showing that DNA can activate TLR9 in a sequence-independent manner.
Comment on
-
The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation.Immunity. 2008 Mar;28(3):315-23. doi: 10.1016/j.immuni.2008.01.013. Immunity. 2008. PMID: 18342006
Similar articles
-
The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation.Immunity. 2008 Mar;28(3):315-23. doi: 10.1016/j.immuni.2008.01.013. Immunity. 2008. PMID: 18342006
-
Ligand-induced conformational changes allosterically activate Toll-like receptor 9.Nat Immunol. 2007 Jul;8(7):772-9. doi: 10.1038/ni1479. Epub 2007 Jun 17. Nat Immunol. 2007. PMID: 17572678
-
TLR9 in health and disease.Int Rev Immunol. 2006 May-Aug;25(3-4):155-81. doi: 10.1080/08830180600743107. Int Rev Immunol. 2006. PMID: 16818370 Review.
-
The sweetness of the DNA backbone drives Toll-like receptor 9.Curr Opin Immunol. 2008 Aug;20(4):396-400. doi: 10.1016/j.coi.2008.06.013. Epub 2008 Jul 30. Curr Opin Immunol. 2008. PMID: 18656540 Review.
-
Innate immune recognition of, and regulation by, DNA.Trends Immunol. 2006 Nov;27(11):525-32. doi: 10.1016/j.it.2006.09.002. Epub 2006 Sep 18. Trends Immunol. 2006. PMID: 16979939 Review.
Cited by
-
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection.Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14879-84. doi: 10.1073/pnas.1104780108. Epub 2011 Aug 22. Proc Natl Acad Sci U S A. 2011. PMID: 21873236 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
