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Review
. 2008 Mar;28(3):293-4.
doi: 10.1016/j.immuni.2008.02.009.

Baseless assumptions: activation of TLR9 by DNA

Monique Gangloff  1 , Nicholas J Gay
Affiliations
Free article
Review

Baseless assumptions: activation of TLR9 by DNA

Monique Gangloff et al. Immunity. 2008 Mar.
Free article

Abstract

The Toll-like receptor 9 (TLR9) is activated by DNA presented in acidified, intracellular compartments. Previous studies suggested that signaling required unmethylated CpG dinucleotides, but in this issue of Immunity, Haas et al. (2008) challenge this view, showing that DNA can activate TLR9 in a sequence-independent manner.

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