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Review
. 2008 Aug;34(8):837-843.
doi: 10.1016/j.ejso.2008.01.029. Epub 2008 Mar 17.

Breast cancer during pregnancy: a mini-review

I Navrozoglou  1 , T Vrekoussis  2 , E Kontostolis  2 , V Dousias  2 , S Zervoudis  3 , E N Stathopoulos  4 , O Zoras  5 , E Paraskevaidis  2
Affiliations
Review

Breast cancer during pregnancy: a mini-review

I Navrozoglou et al. Eur J Surg Oncol. 2008 Aug.

Abstract

Background: As modern women delay childbearing, pregnancy-associated breast cancer (PABC) becomes a more frequent problem faced by oncologists, gynecologists, and obstetricians alike. However, no evidence exists concerning the management of this condition.

Methods: We summarized the current literature regarding epidemiology, pathology, diagnosis, treatment and prognosis of PABC. Data were collected by searching PubMed and Medline for the period from 1950 to 2007.

Results: There are no randomized controlled trials regarding PABC management. Current evidence suggests that diagnosis may be carried out with limitations regarding staging; surgical treatment may be performed as for the non-pregnant women. Radiotherapy and endocrine therapy are contraindicated during pregnancy, while chemotherapy is allowed after the first trimester. Prognosis is considered poor. Subsequent pregnancy is allowed only 2 years after completing treatment.

Conclusions: Due to lack of prospective randomized controlled clinical studies, both ongoing studies and future evidence are expected to solve problems related to breast cancer management during pregnancy.

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