doi: 10.1016/0006-8993(91)90362-y.
Increase in D2 dopamine receptors in the substantia nigra after chronic (-)-sulpiride treatment
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- PMID: 1834311
- DOI: 10.1016/0006-8993(91)90362-y
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Increase in D2 dopamine receptors in the substantia nigra after chronic (-)-sulpiride treatment
Brain Res.
.
Abstract
Changes in D2 dopamine (DA) receptors in the substantia nigra (SN) and caudate nucleus (CN) homogenates were studied in rats following chronic treatment with the specific D2 receptor antagonist (-)-sulpiride (50 mg/kg s.c. twice daily for 8 days). Sixty hours after (-)-sulpiride withdrawal, the Bmax of [3H]spiroperidol binding (in the presence of 30 Nm ketanserin) was found to be increased by 76% and 38% in the SN and CN, respectively. No changes in the KdS were observed. The findings suggest that chronic (-)-sulpiride results in the upregulation of DA autoreceptors in the SN.
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