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Comparative Study
. 2008 May;179(5):1704-8.
doi: 10.1016/j.juro.2008.01.027. Epub 2008 Mar 17.

Racial/ethnic and gender disparities in renal cell carcinoma incidence and survival

Helen Shi Stafford  1 , Sidney L Saltzstein, Suzuho Shimasaki, Catherine Sanders, Tracy M Downs, Georgia Robins Sadler
Affiliations
Comparative Study

Racial/ethnic and gender disparities in renal cell carcinoma incidence and survival

Helen Shi Stafford et al. J Urol. 2008 May.

Abstract

Purpose: We used a population based cancer registry to examine trends in renal cell carcinoma incidence and survival among 4 racial/ethnic groups (white, black, Hispanic and Asian/Pacific Islander) and both genders.

Materials and methods: Race/ethnicity, gender, age, staging, length of survival and cause of death data were analyzed using 39,434 cases of renal cell carcinoma from 1988 to 2004 from the California Cancer Registry. Annual age adjusted incidence rates and relative survival rates were calculated for the racial/ethnic and gender groups. These rates and the percent of localized cancer were plotted by year, and Microsoft Excel was used to calculate linear regression equations. Median age was also calculated. Z-tests and chi-square tests were performed to determine p values.

Results: An increase in renal cell carcinoma incidence was found with localized cancer accounting for most of the increase. Black patients had a significantly higher incidence rate (p <0.0001) and lower survival rate (p <0.0001) than all other races/ethnicities despite having more localized cancer (p <0.005). Black patients were also diagnosed at a younger age (p <0.0001) than their counterparts. On the other hand Asian/Pacific Islanders had a lower incidence rate (p <0.0001) and higher survival rate (p <0.05) than all other races/ethnicities. Males had approximately twice the incidence rate of females and a lower survival rate (p <0.005).

Conclusions: Higher incidence rates and lower survival rates were identified among black and male patients compared to their counterparts, while Asian/Pacific Islanders showed the opposite trends. Such racial/ethnic and gender disparities in renal cell carcinoma incidence and survival may help elucidate biological, behavioral and environmental factors that can potentially be addressed.

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Figures

Figure 1
Figure 1
Renal cell carcinoma: age-adjusted incidence rate from 1988–2004 by gender
Figure 2
Figure 2
Renal cell carcinoma: age-adjusted incidence rate from 1988–2004 by race/ethnicity
Figure 3
Figure 3
Renal cell carcinoma: percent local stage from 1988–2004
Figure 4
Figure 4
Renal cell carcinoma: relative cumulative actuarial survival from 1988–2004 by race/ethnicity
Figure 5
Figure 5
Localized renal cell carcinoma: relative cumulative actuarial survival from 1988–2004 by race/ethnicity
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References

    1. American Cancer Society. Cancer Facts and Figures 2007. 2007.

    1. SEER Program Public Use Data Tapes 1973–2002, November 2004 Submission. Bethesda. National Cancer Institute, Division of Cancer Control and Population Science, Surveillance Research Program, Cancer Statistics Branch, 2005

    1. Mufti GR, Gove JR, Badenoch DF, Fowler CG, Tiptaft RC, England HR, et al. Transitional cell carcinoma of the renal pelvis and ureter. Br J Urol. 1989;63:135. - PubMed
    1. Cancer incidence in five continents. VIII. IARC Sci Publ; 2002. p. 1. - PubMed
    1. Lipworth L, Tarone RE, McLaughlin JK. The epidemiology of renal cell carcinoma. J Urol. 2006;176:2353. - PubMed

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