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Review
. 2009 Mar;57(2):197-202.
doi: 10.1016/j.patbio.2008.01.001. Epub 2008 Mar 17.

[Human bocavirus (HBoV)]

[Article in French]
V Foulongne  1 , M Segondy
Affiliations
Review

[Human bocavirus (HBoV)]

[Article in French]
V Foulongne et al. Pathol Biol (Paris). 2009 Mar.

Abstract
in English, French

The human bocavirus (HBoV) has been recently identified by means of molecular screening techniques in respiratory tract secretions from children with acute respiratory tract disease. This virus, which belongs to the Parvoviridae family, has been detected worldwide with a 5 to 10% prevalence among children with upper or lower respiratory tract infections, essentially during the winter period. A seroepidemiological study has shown that almost all the children have antibodies to HBoV by the age of five years, and HBoV infection seems to be rare in adults. HBoV is often detected in association with other respiratory viruses. This virus has also been detected in stools, but its role in gastroenteritis has not been yet established. Virological diagnostic of HBoV infection is based on the detection of viral DNA by PCR. Viral load determination by viral DNA quantitation in respiratory tract secretions could be a tool to differentiate between symptomatic HBoV infection and virus carriage.

Le bocavirus humain (HBoV) a été récemment identifié dans les sécrétions respiratoires de sujets présentant une atteinte respiratoire aiguë grâce à l’utilisation de techniques de criblage moléculaire. Ce virus qui appartient à la famille des Parvoviridae a été retrouvé dans toutes les régions du monde avec une prévalence de l’ordre de 5 à 10 % chez les enfants présentant des atteintes respiratoires hautes ou basses, essentiellement en période hivernale. Une étude séroépidémiologique a montré que pratiquement tous les enfants étaient porteurs d’anticorps à l’âge de cinq ans et l’infection paraît rare chez l’adulte. Ce virus est souvent retrouvé en association avec d’autres virus respiratoires. Le virus a été retrouvé également dans les selles, mais son rôle dans les gastroentérites n’a pas été établi. Le diagnostic virologique repose sur la détection d’ADN viral par PCR. La charge virale, déterminée dans les sécrétions respiratoires par quantification de l’ADN viral, pourrait permettre de différencier une infection symptomatique d’un simple portage du virus.

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