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. 2008 Mar;101(3):148-55.
doi: 10.1258/jrsm.2008.081005.

The use of historical controls and concurrent controls to assess the effects of sulphonamides, 1936-1945

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The use of historical controls and concurrent controls to assess the effects of sulphonamides, 1936-1945

Irvine Loudon. J R Soc Med. 2008 Mar.
No abstract available

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Figures

Figure 1
Figure 1
The chemical structure of prontosil rubrum and sulphanilamide

References

    1. Glasziou P, Chalmers I, Rawlins M, McCulloch P. When are randomised trials unnecessary? Picking signal from noise. BMJ. 2007;334:349–51. - PMC - PubMed
    1. Colebrook L, Kenny M. Treatment of human puerperal infections, and of experimental infections in mice, with prontosil. Lancet. 1936;1:1279–86.
    1. Colebrook L, Kenny M. Treatment with prontosil of puerperal infections due to haemolytic streptococci. Lancet. 1936;2:1319–22.
    1. Colebrook L, Purdie AW. Treatment of 106 cases of puerperal fever by sulphanilamide. Lancet. 1937;2:1291–4. and 1237–42.
    1. Banks HS. Chemotherapy of meningococcal meningitis. Lancet. 1939;2:921–7.

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