Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2008 Mar 15;22(6):706-10.
doi: 10.1101/gad.1662408.

A house with many rooms: how the heart got its chambers with foxn4

Ethan David Cohen  1 , Edward E Morrisey
Affiliations
Comment

A house with many rooms: how the heart got its chambers with foxn4

Ethan David Cohen et al. Genes Dev. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Development of a simple vessel into a two-chambered heart using foxn4–tbx2b. (A) The zebrafish heart begins as a simple vessel containing myocardial (red), epicardial (blue), and endocardial (green) cells. The zebrafish heart resembles the dorsal vessel in insects at this stage, except for the presence of epicardial cells in the vertebrate heart, and pumps blood primarily by peristaltic action. (B) Upon expression of foxn4, which activates tbx2b expression, the endocardial cells ingress inward, forming the AV canal, forming a valve, and causing a conduction delay required for setting up a unidirectional circulation. (C) Finally, the mature two-chambered heart with mature valves can circulate blood with high efficiency in a closed system. Arrows indicate both blood flow and direction of electrical conduction in the developing zebrafish heart.
See this image and copyright information in PMC

Comment on

References

    1. Basson C.T., Bachinsky D.R., Lin R.C., Levi T., Elkins J.A., Soults J., Grayzel D., Kroumpouzou E., Traill T.A., Leblanc-Straceski J., et al. Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat. Genet. 1997;15:30–35. - PubMed
    1. Bruneau B.G., Nemer G., Schmitt J.P., Charron F., Robitaille L., Caron S., Conner D.A., Gessler M., Nemer M., Seidman C.E., et al. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell. 2001;106:709–721. - PubMed
    1. Cai C.L., Zhou W., Yang L., Bu L., Qyang Y., Zhang X., Li X., Rosenfeld M.G., Chen J., Evans S. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development. 2005;132:2475–2487. - PMC - PubMed
    1. Chi N.C., Shaw R.M., De Val S., Kang G., Jan L.Y., Black B.L., Stainier D.Y.R. Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes & Dev. 2008 doi: 10.1101/gad.1629408. (this issue) - DOI - PMC - PubMed
    1. Christoffels V.M., Hoogaars W.M., Tessari A., Clout D.E., Moorman A.F., Campione M. T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev. Dyn. 2004;229:763–770. - PubMed

Publication types

MeSH terms

LinkOut - more resources