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Comparative Study
. 2008 Spring;13(1):31-8.
doi: 10.1007/s12192-007-0005-1. Epub 2008 Feb 5.

Prevention of chemotherapy-induced alopecia in rodent models

Joaquin J Jimenez  1 , Stephen M Roberts, Jessica Mejia, Lucia M Mauro, John W Munson, George W Elgart, Elizabeth Alvarez Connelly, Qingbin Chen, Jiangying Zou, Carlos Goldenberg, Richard Voellmy
Affiliations
Comparative Study

Prevention of chemotherapy-induced alopecia in rodent models

Joaquin J Jimenez et al. Cell Stress Chaperones. 2008 Spring.

Abstract

Alopecia (hair loss) is experienced by thousands of cancer patients every year. Substantial-to-severe alopecia is induced by anthracyclines (e.g., adriamycin), taxanes (e.g., taxol), alkylating compounds (e.g., cyclophosphamide), and the topisomerase inhibitor etoposide, agents that are widely used in the treatment of leukemias and breast, lung, ovarian, and bladder cancers. Currently, no treatment appears to be generally effective in reliably preventing this secondary effect of chemotherapy. We observed in experiments using different rodent models that localized administration of heat or subcutaneous/intradermal injection of geldanamycin or 17-(allylamino)-17-demethoxygeldanamycin induced a stress protein response in hair follicles and effectively prevented alopecia from adriamycin, cyclophosphamide, taxol, and etoposide. Model tumor therapy experiments support the presumption that such localized hair-saving treatment does not negatively affect chemotherapy efficacy.

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Figures

Fig. 1
Fig. 1
Localized protection of hair from the toxicity of antineoplastic agents in young rodent models. a Heat-induced protection from etoposide toxicity in the young rat model. Groups of animals are shown that were heat-treated at the nape of the neck or not heat-treated before drug administration. b Untreated young rat. c Skin sections from the nape of the neck of untreated or heat-treated young rats immunostained for Hsp70 (brown color). d Protection from etoposide toxicity in the young rat model induced by an activator of the stress protein response. Groups of young rats are shown that were injected s.c. with GA in the nape of the neck before etoposide administration. e Heat-induced protection of hair (on the lower back) from cyclophosphamide toxicity in a young mouse model. GA geldanamycin (for experimental detail see the text)
Fig. 2
Fig. 2
a and b Localized protection of hair on the lower back of adult mice from cyclophosphamide toxicity. Protective effects were induced in a by laser heat and in b by 17AAG. c Model cancer chemotherapy experiment using the young rat model. 17AAG 17-(allylamino)-17-demethoxygeldanamycin, Cyc cyclophosphamide (for experimental detail see the text)
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References

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