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. 1991 Nov 7;354(6348):31-7.
doi: 10.1038/354031a0.

Molecular cloning and characterization of the rat NMDA receptor

K Moriyoshi  1 , M Masu, T Ishii, R Shigemoto, N Mizuno, S Nakanishi
Affiliations

Molecular cloning and characterization of the rat NMDA receptor

K Moriyoshi et al. Nature. .

Abstract

A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.

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