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. 2008 Mar 28;14(12):1931-5.
doi: 10.3748/wjg.14.1931.

Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer

Kai-Xing Ai  1 , Lin-Yuan Lu, Xin-Yu Huang, Wei Chen, Hui-Zhen Zhang
Affiliations

Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer

Kai-Xing Ai et al. World J Gastroenterol. .

Abstract

Aim: To investigate the expression of vascular endothelial growth factor (VEGF) and calcium-binding protein S100A4 in pancreatic cancer and their relationship to the clinicopathological parameters and prognosis of pancreatic cancer.

Methods: Expression status of VEGF and S100A4 was examined in 62 surgical specimens of primary pancreatic cancer by immunohistochemistry. Correlation between the expression of VEGF and S100A4 and clinicopathological parameters was analyzed.

Results: Thirty-eight of 62 (61.3%) specimens of primary pancreatic cancer were positive for S100A4. Thirty-seven (59.7%) specimens showed positive expression of VEGF. The positive correlation between S100A4 and VEGF expression was significant in cancer tissues (P < 0.001). S100A4 expression was significantly correlated with tumor size, TNM stage and poorer prognosis. VEGF expression had a significant correlation with poorer prognosis. The prognosis of 17 S100A4- and VEGF-negative cancer patients was significantly better than that of other patients (P < 0.05). Distant metastasis (P = 0.001), S100A4- (P = 0.008) and VEGF-positive expression (P = 0.016) were significantly independent prognostic predictors (P < 0.05).

Conclusion: Over-expression of S100A4 and VEGF plays an important role in the development of pancreatic cancer. Combined examination of the two molecules might be useful in evaluating the outcome of patients with pancreatic cancer.

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Figures

Figure 1
Figure 1
Positive expression of S100A4 (A) and VEGF (B) in pancreatic cancer (× 200).
Figure 2
Figure 2
Survival curves for group of pancreatic cancer patients according to S100A4 expression (A), group of pancreatic cancer patients according to VEGF expression (B), and four subgroups of pancreatic cancer patients according to the expression of S100A4 and VEGF (C).
See this image and copyright information in PMC

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