This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

. 2008 May 5;9(7):1024-8.

doi: 10.1002/cbic.200700703.

Structure and mechanistic implications of a tryptophan synthase quinonoid intermediate

Thomas R M Barends¹, Tatiana Domratcheva, Victor Kulik, Lars Blumenstein, Dimitri Niks, Michael F Dunn, Ilme Schlichting

Affiliations

PMID: 18351684
DOI: 10.1002/cbic.200700703

Structure and mechanistic implications of a tryptophan synthase quinonoid intermediate

Thomas R M Barends et al. Chembiochem. 2008.

. 2008 May 5;9(7):1024-8.

doi: 10.1002/cbic.200700703.

Authors

Thomas R M Barends¹, Tatiana Domratcheva, Victor Kulik, Lars Blumenstein, Dimitri Niks, Michael F Dunn, Ilme Schlichting

Affiliation

¹ Abteilung Biomolekulare Mechanismen, Max Planck Institut für Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.

PMID: 18351684
DOI: 10.1002/cbic.200700703

No abstract available

PubMed Disclaimer

Similar articles

Tryptophan synthase, an allosteric molecular factory.
Barends TR, Dunn MF, Schlichting I. Barends TR, et al. Curr Opin Chem Biol. 2008 Oct;12(5):593-600. doi: 10.1016/j.cbpa.2008.07.011. Curr Opin Chem Biol. 2008. PMID: 18675375
The reaction of indole with the aminoacrylate intermediate of Salmonella typhimurium tryptophan synthase: observation of a primary kinetic isotope effect with 3-[(2)H]indole.
Cash MT, Miles EW, Phillips RS. Cash MT, et al. Arch Biochem Biophys. 2004 Dec 15;432(2):233-43. doi: 10.1016/j.abb.2004.09.027. Arch Biochem Biophys. 2004. PMID: 15542062
Structural and functional alterations of E. coli tryptophan synthase upon binding of pyridoxal 5'-phosphate.
Bartholmes P. Bartholmes P. Prog Clin Biol Res. 1984;144A:309-17. Prog Clin Biol Res. 1984. PMID: 6427784 No abstract available.
Tryptophan synthase: a mine for enzymologists.
Raboni S, Bettati S, Mozzarelli A. Raboni S, et al. Cell Mol Life Sci. 2009 Jul;66(14):2391-403. doi: 10.1007/s00018-009-0028-0. Epub 2009 Apr 22. Cell Mol Life Sci. 2009. PMID: 19387555 Free PMC article. Review.
Stereospecificity of alpha-proton exchange reactions catalysed by pyridoxal-5'-phosphate-dependent enzymes.
Malthouse JP. Malthouse JP. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):138-42. doi: 10.1016/s1570-9639(03)00080-3. Biochim Biophys Acta. 2003. PMID: 12686123 Review.

See all similar articles

Cited by

Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex.
Dunn MF. Dunn MF. Arch Biochem Biophys. 2012 Mar 15;519(2):154-66. doi: 10.1016/j.abb.2012.01.016. Epub 2012 Feb 2. Arch Biochem Biophys. 2012. PMID: 22310642 Free PMC article. Review.
Discovery of antimicrobial agent targeting tryptophan synthase.
Bosken YK, Ai R, Hilario E, Ghosh RK, Dunn MF, Kan SH, Niks D, Zhou H, Ma W, Mueller LJ, Fan L, Chang CA. Bosken YK, et al. Protein Sci. 2022 Feb;31(2):432-442. doi: 10.1002/pro.4236. Epub 2021 Nov 26. Protein Sci. 2022. PMID: 34767267 Free PMC article.
In Silico Identification and Experimental Validation of Distal Activity-Enhancing Mutations in Tryptophan Synthase.
Maria-Solano MA, Kinateder T, Iglesias-Fernández J, Sterner R, Osuna S. Maria-Solano MA, et al. ACS Catal. 2021 Nov 5;11(21):13733-13743. doi: 10.1021/acscatal.1c03950. Epub 2021 Oct 28. ACS Catal. 2021. PMID: 34777912 Free PMC article.
Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states.
Niks D, Hilario E, Dierkers A, Ngo H, Borchardt D, Neubauer TJ, Fan L, Mueller LJ, Dunn MF. Niks D, et al. Biochemistry. 2013 Sep 17;52(37):6396-411. doi: 10.1021/bi400795e. Epub 2013 Sep 6. Biochemistry. 2013. PMID: 23952479 Free PMC article.
Severing of a hydrogen bond disrupts amino acid networks in the catalytically active state of the alpha subunit of tryptophan synthase.
Axe JM, O'Rourke KF, Kerstetter NE, Yezdimer EM, Chan YM, Chasin A, Boehr DD. Axe JM, et al. Protein Sci. 2015 Apr;24(4):484-94. doi: 10.1002/pro.2598. Epub 2014 Dec 11. Protein Sci. 2015. PMID: 25377949 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

Grants and funding

GM5574/GM/NIGMS NIH HHS/United States

LinkOut - more resources

Full Text Sources
- Wiley