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Review
. 2008 Mar;15(2):91-8.
doi: 10.1155/2008/416095.

The link between allergic rhinitis and asthma: a role for antileukotrienes?

[Article in English, French]
H Kim  1 , J Bouchard, P M Renzi
Affiliations
Review

The link between allergic rhinitis and asthma: a role for antileukotrienes?

[Article in English, French]
H Kim et al. Can Respir J. 2008 Mar.

Abstract
in English, French

Allergic rhinitis and asthma are both chronic heterogeneous disorders, with an overlapping epidemiology of prevalence, health care costs and social costs in quality of life. Both are inflammatory disorders with a similar pathophysiology, and both share some treatment approaches. However, each disorder has an array of treatments used separately in controlling these atopic disorders, from inhaled corticosteroids, beta(2)-agonists and antihistamines to newer monoclonal antibody-based treatments. The present article reviews the shared components of allergic rhinitis and asthma, and examines recent evidence supporting antileukotrienes as effective agents in reducing the symptoms of both diseases.

La rhinite allergique et l’asthme sont deux troubles hétérogènes chroniques dont l’épidémiologie de la prévalence, les coûts de santé et les coûts sociaux en matière de qualité de vie se chevauchent. Ce sont deux troubles inflammatoires à la physiopathologie similaire, et tous deux partagent certaines approches thérapeutiques. Cependant, chacun de ces troubles atopiques comporte toute une série de traitements de contrôle utilisés séparément, qu’il s’agisse des corticoïdes en aérosol, des bêta2-agonistes et des antihistaminiques ou des traitements plus récents à base d’anticorps monoclonaux. Le présent article passe en revue les éléments que partagent la rhinite allergique et l’asthme ainsi que les données probantes récentes qui appuient le rôle des antileukotriènes comme agents efficaces en vue de réduire les symptômes de ces deux maladies.

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Figures

Figure 1)
Figure 1)
The inflammatory process involves crosstalk among the bone marrow, the inflammatory cells, and the upper and lower airways. Adapted from references and
See this image and copyright information in PMC

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