Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Feb;41(2):111-5.
doi: 10.1016/j.jcv.2007.10.007.

The prevalence of human papillomavirus (HPV) infection in paired urine and cervical smear samples of HIV-infected women

Eefje Jong  1 , Jan Willem Mulder, Eric C M van Gorp, Jiri K S Wagenaar, Joke Derksen, Johan Westerga, Anja Tol, Paul H M Smits
Affiliations

The prevalence of human papillomavirus (HPV) infection in paired urine and cervical smear samples of HIV-infected women

Eefje Jong et al. J Clin Virol. 2008 Feb.

Abstract

Background: HIV-infected women are at increased risk for cervical dysplasia. Cervical dysplasia is caused by persistent infections with certain types of human papillomavirus (HPV). Conventional testing for genital HPV infections requires cervical cytology. A non-invasive screening method by detection of HPV DNA in urine samples is preferable but is not a routine practice.

Objectives: To investigate the prevalence and concordance of HPV in paired urine and cervical smear samples and cytological results of Pap smears in HIV-infected women.

Study design: Paired urine and cervical smear samples were collected from 27 HIV-infected women.

Results: The HPV prevalence in urine and cervical smear samples was 81.5% and 51.9%, respectively (p = 0.01). The concordance for HPV positivity and negativity between urine and cervical smear samples is 71%. Seven women (25.9%) had an abnormal cervical smear of Pap II or higher. In all urine samples from these cases HPV DNA was detected.

Conclusion: In the present study we show that the HPV prevalence in urine and cervical smear samples of HIV-infected women is high and HPV test results are highly concordant. Therefore, urine samples can be used as medium for HPV testing. HPV testing in urine samples is a simple, reliable, non-invasive screening method.

PubMed Disclaimer

Publication types