doi: 10.1021/ja8006325.
Epub 2008 Mar 20.
Robust, efficient, and orthogonal synthesis of dendrimers via thiol-ene "click" chemistry
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- PMID: 18355008
- DOI: 10.1021/ja8006325
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Robust, efficient, and orthogonal synthesis of dendrimers via thiol-ene "click" chemistry
J Am Chem Soc.
.
Free article
Abstract
Dendrimers up to the fourth generation were successfully prepared via the divergent growth strategy using a combination of thiol-ene "click" chemistry and traditional esterification reactions. The thiol-ene reactions were conducted under solvent-free, ambient conditions at room temperature by irradiating with UV light. The fourth-generation dendrimers were subsequently functionalized with carboxylic acid, pyrene, and Fmoc-protected cysteine moieties via thiol-ene reactions.
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