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. 2008 May;15(5):458-64.
doi: 10.1111/j.1468-1331.2008.02108.x. Epub 2008 Mar 18.

Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK

I Bone  1 , L Belton, A S Walker, J Darbyshire
Affiliations

Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK

I Bone et al. Eur J Neurol. 2008 May.

Abstract

BACKGROUND, PURPOSE AND METHODS: This observational study assessed the effect of continuous intraventricular infusion of pentosan polysulphate (PPS) in seven patients at different clinical centres in the UK.

Results: Complications of intraventricular catheterization were frequent. PPS was well-tolerated over a wide dose range (11-110 microg/kg/day) during the 6-month study. Four patients were assessed for the entire study period: one remained stable, two showed minimal deterioration and one progressed significantly.

Conclusion: Mean survival of all patients was longer than reported values for natural history of specific prion disorders. Possible reasons for these findings are explored.

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Comment in

  • Creutzfeldt-Jakob disease: hopes for therapy.
    Pocchiari M, Ladogana A, Graziano S, Puopolo M. Pocchiari M, et al. Eur J Neurol. 2008 May;15(5):435-6. doi: 10.1111/j.1468-1331.2008.02109.x. Eur J Neurol. 2008. PMID: 18394045 No abstract available.

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