Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2008 Apr;85(4):1430-2.
doi: 10.1016/j.athoracsur.2007.10.012.

Novel germline mutation: EGFR V843I in patient with multiple lung adenocarcinomas and family members with lung cancer

Koei Ikeda  1 , Hiroaki Nomori, Takeshi Mori, Jiichiro Sasaki, Toshiaki Kobayashi
Affiliations
Case Reports

Novel germline mutation: EGFR V843I in patient with multiple lung adenocarcinomas and family members with lung cancer

Koei Ikeda et al. Ann Thorac Surg. 2008 Apr.

Abstract

A novel germline transmission of the epidermal growth factor receptor (EGFR) mutation V843I in a family with multiple members with lung cancer is reported. The proband was a 70-year-old woman with multiple adenocarcinomas who exhibited secondary EGFR mutations, either L858R or L861Q, in the specimens of resected tumors, in addition to a germline EGFR V843I mutation. These observations suggest that the germline EGFR V843I mutation might have altered EGFR signaling in the multicentric development of adenocarcinoma, bronchoalveolar carcinoma, and atypical adenomatous hyperplasia and also might have had a role in the development of lung cancer in multiple members of her family.

PubMed Disclaimer

Publication types

MeSH terms