Successful treatment of invasive Aspergillus sinusitis with caspofungin and voriconazole

Abstract

Chronic invasive Aspergillus sinusitis is a rare and potentially devastating infection. Management typically requires extensive surgical debridement followed by long-term antifungal therapy, primarily with intravenous amphotericin B. We describe the case of an elderly woman who had been diagnosed with extensive Aspergillus sinusitis that had invaded critical structures. The extensiveness of the infection and the patients frailty and unwillingness to undergo a disfiguring procedure precluded surgery, and her medical condition was too fragile to withstandamphotericin B therapy Therefore, we decided to treat her with a combination ofcaspofungin and voriconazole, two relatively nontoxic antifungal agents that have different mechanisms of action. After administration of this novel regimen, the infection resolved rapidly.