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Review
. 2008 Apr;108(4 Suppl 1):S66-72.
doi: 10.1016/j.jada.2008.01.026.

Implications of the diabetes prevention program and Look AHEAD clinical trials for lifestyle interventions

Linda M Delahanty  1 , David M Nathan
Affiliations
Review

Implications of the diabetes prevention program and Look AHEAD clinical trials for lifestyle interventions

Linda M Delahanty et al. J Am Diet Assoc. 2008 Apr.

Abstract

The Diabetes Prevention Program (DPP) and Look AHEAD (Action for Health in Diabetes) trials are long-term randomized clinical trials that have the potential to direct diabetes care and medical nutrition therapy for obesity, prediabetes, and type 2 diabetes both now and in the future. This article summarizes and compares the important evidence-based results of these diabetes and obesity clinical trials and reviews the similarities and differences in lifestyle interventions that were designed for these trials. Although there were many similarities in the features of the DPP and Look AHEAD interventions, the Look AHEAD lifestyle intervention was more ambitious in several ways: higher individual weight-loss goals, lower calorie and fat-gram targets based on initial body weight, more intensive intervention frequency, combining closed group and individual session format, and use of more structured nutrition intervention strategies from the outset, including meal replacements, structured menus, and combined fat and calorie counting. Evidence, knowledge, and insights gained from working on these clinical trials will be very important in determining the strategies, methods, and approaches needed to make sure that the results of these trials will be fully applied in real-world practice settings for obesity, prediabetes, and type 2 diabetes.

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Figures

Figure 1
Figure 1
Translating Lifestyle interventions to Clinical Practice Settings
See this image and copyright information in PMC

References

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    1. Look AHEAD Research Group. Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Con Clin Trials. 2003;24:610–628. - PubMed
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    1. Look AHEAD Research Group. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes. Diabetes Care. 2007;30:1374–1383. - PMC - PubMed
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