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Review
. 2008 Apr;20(2):164-70.
doi: 10.1016/j.ceb.2008.02.003. Epub 2008 Mar 21.

GATA-3 and the regulation of the mammary luminal cell fate

Hosein Kouros-Mehr  1 , Jung-whan Kim, Seth K Bechis, Zena Werb
Affiliations
Review

GATA-3 and the regulation of the mammary luminal cell fate

Hosein Kouros-Mehr et al. Curr Opin Cell Biol. 2008 Apr.

Abstract

The GATA family of transcription factors plays essential roles in the specification and maintenance of differentiated cell types. GATA-3 was identified in a microarray screen of the mouse mammary gland as the most highly expressed transcription factor in the mammary epithelium and is expressed exclusively in the luminal epithelial cell population. Targeted deletion of GATA-3 in mammary glands leads to profound defects in mammary development and inability to specify and maintain the luminal cell fate in the adult mouse. In breast cancer, GATA-3 has emerged as a strong predictor of tumor differentiation, estrogen-receptor status, and clinical outcome. GATA-3 maintains tumor differentiation and suppresses tumor dissemination in a mouse model of breast cancer. This review explores our current understanding of GATA-3 signaling in luminal cell differentiation, both in mammary development and breast cancer.

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Figures

Figure 1
Figure 1
(A) Schematic representation of the role of GATA-3 in specifying and maintaining the luminal cell fate in the mammary gland. (B) A simplified gene regulatory network depicting the known interactions between GATA-3 and other transcriptional regulators in the mammary gland. Not shown are transcription factors that are essential for lobulo-alveolar development, including C/EBPβ, Id2, Stat5a, HoxA9, HoxB9, and HoxD9.
See this image and copyright information in PMC

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