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. 2008 Mar 21;132(6):917-8.
doi: 10.1016/j.cell.2008.03.003.

Transcription termination: pulling out all the stops

Jack F Greenblatt  1
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Transcription termination: pulling out all the stops

Jack F Greenblatt. Cell. .
Free article

Abstract

In this issue, Larson et al. (2008) describe the use of optical traps to pull on the DNA template or RNA transcript and thereby explore the termination mechanism for E. coli RNA polymerase at intrinsic terminators. Their results imply that, depending on the nature of the terminator sequence, RNA polymerase uses either hypertranslocation or RNA:DNA shearing to destabilize the hybrid in the transcription bubble.

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