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. 2008 Apr;34(4):570-7.
doi: 10.1016/j.jcrs.2007.11.052.

Efficacy of neural vision therapy to enhance contrast sensitivity function and visual acuity in low myopia

Donald T H Tan  1 , Allan Fong
Affiliations

Efficacy of neural vision therapy to enhance contrast sensitivity function and visual acuity in low myopia

Donald T H Tan et al. J Cataract Refract Surg. 2008 Apr.

Abstract

Purpose: To evaluate the efficacy and safety of neural vision enhancement technology (NVC, NeuroVision, Inc.) to improve visual acuity and contrast sensitivity function in eyes with low myopia.

Setting: Singapore Eye Research Institute, Singapore, Singapore.

Methods: This noncomparative interventional case series comprised 20 Asian adults between 19 and 53 years of age with low myopia (cycloplegic spherical equivalence [SE] from -0.5 diopter [D] to -1.5 D in the worst eye; astigmatism not exceeding 0.5 D in either eye; uncorrected visual acuity [UCVA] < or =0.7 logMAR) who had NVC treatment. The main outcome measures were distance UCVA, uncorrected contrast sensitivity, refraction, accommodative amplitude, and safety.

Results: All eyes had improvement in UCVA and contrast sensitivity. After treatment, the mean distance UCVA improved by a mean of 2.1 lines on the Early Treatment Diabetic Retinopathy Study logMAR chart. The mean contrast sensitivity improved over a range of spatial frequencies on sine-wave contrast sensitivity chart testing (1.5 to 18 cycles per degree). Follow-up data up to 12 months posttreatment showed that the gains were retained. Treatment did not alter refraction (mean spherical equivalent) or accommodative amplitudes. No adverse effects were reported.

Conclusion: Preliminary evidence suggests NVC treatment is safe and improves UCVA and uncorrected contrast sensitivity in adult patients with low myopia.

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Figures

Figure 1
Figure 1
Manipulation of Gabor stimuli.
Figure 2
Figure 2
Improvement in UCVA immediately after treatment in 40 eyes of the 20 patients before and after NVC treatment. Open circles indicate the initial pretreatment UCVA in each eye. The yellow triangles indicare the level of UCVA at termination of treatment in each corresponding eye.
Figure 3
Figure 3
Vision retention 6 months after treatment (n = 16) (Base = baseline; EOT = end of treatment; M = month).
Figure 4
Figure 4
Vision retention at 12 months after treatment (n = 11) (Base = baseline; EOT = end of treatment; M = month).
Figure 5
Figure 5
Contrast sensitivity function before and after treatment (mean of 11 patients with 12-month follow-up).
Figure 6
Figure 6
Dependency on glasses/contact lenses (“How many times a week do you wear your glasses/contact lenses?”).
Figure 7
Figure 7
Dependency on glasses/contact lenses after treatment (“Following treatment, do you use your glasses/contact lenses less than before?”).
See this image and copyright information in PMC

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