When should children with HIV infection be started on antiretroviral therapy?
- PMID: 18366251
- PMCID: PMC2270305
- DOI: 10.1371/journal.pmed.0050073
When should children with HIV infection be started on antiretroviral therapy?
Abstract
The advent of highly active antiretroviral therapy (HAART) dramatically improved the prognosis for both adults and children infected with HIV who had access to treatment. However, the optimal timing for initiating treatment remains controversial, particularly in children. This debate lays out the case for deferred treatment against the case for early initiation of HAART in children.
Conflict of interest statement
References
-
- Violari A, Cotton M, Gibb D. Antiretroviral therapy initiated before 12 weeks of age reduces early mortality in young HIV-infected infants: Evidence from the Children with HIV Early Antiretroviral Therapy (CHER) Study [Abstract WESS103] 2007. 4th IAS Conference on HIV Pathogenesis, Treatment, and Prevention; 22–25 July 2007; Sydney, Australia. Available: http://www.ias2007.org/pag/Abstracts.aspx?AID=5557. Accessed 15 February 2008.
-
- El-Sadr WM, Lundgren JD, Neaton JD, Gordin F, et al. CD4+ count-guided interruption of antiretroviral treatment. N Engl J Med. 2006;355:2283–2296. The Strategies for Management of Antiretroviral Therapy (SMART) Study Group. - PubMed
-
- Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med. 2000;133:21–30. - PubMed
-
- Dunn D. Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral therapy or zidovudine monotherapy: A meta-analysis. Lancet. 2003;362:1605–1611. HIV Paediatric Prognostic Markers Collaborative Study Group. - PubMed
-
- Sharland M, Blanche S, Castelli G, Ramos J, Gibb DM. PENTA guidelines for the use of antiretroviral therapy, 2004. HIV Med. 2004;5(Suppl 2):61–86. on behalf of the PENTA Steering Committee. - PubMed
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical