Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Jan;8(1):66-72.
doi: 10.1007/s11910-008-0011-4.

Statin myopathy

Kristofer A Radcliffe  1 , William W Campbell
Affiliations
Review

Statin myopathy

Kristofer A Radcliffe et al. Curr Neurol Neurosci Rep. 2008 Jan.

Abstract

Many different classes of medications can cause toxic myopathy. One of the most frequently implicated classes is the statins. Statin myotoxicity ranges from asymptomatic creatine kinase elevations or myalgias to muscle necrosis and fatal rhabdomyolysis. Statins may also cause an autoimmune myopathy requiring immunosuppressive treatment. The mechanisms of statin myotoxicity are unclear. If unrecognized in its early manifestations, complications from continued statin therapy may lead to rhabdomyolysis and death. Risk factors for myotoxicity include concomitant medication use and medical conditions, and the patient's underlying genetic constitution. We review these considerations along with the recommended evaluation and treatment for patients presenting with statin myotoxicity.

PubMed Disclaimer

References

    1. Pharmacol Res. 2007 Apr;55(4):310-7 - PubMed
    1. Drugs Today (Barc). 2005 Apr;41(4):267-93 - PubMed
    1. South Med J. 2006 Apr;99(4):403-4 - PubMed
    1. Arch Intern Med. 2005 Dec 12-26;165(22):2671-6 - PubMed
    1. Eur J Clin Pharmacol. 2006 Jun;62(6):473-9 - PubMed

MeSH terms

Substances

LinkOut - more resources