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. 1991 Sep-Oct;21(5):435-40.
doi: 10.1007/BF01200278.

Analysis of two types of dopaminergic responses of neurons of the spinal ganglia of rats

I I Abramets  1 , I M Samoilovich
Affiliations

Analysis of two types of dopaminergic responses of neurons of the spinal ganglia of rats

I I Abramets et al. Neurosci Behav Physiol. 1991 Sep-Oct.

Abstract

It was established, in experiments on isolated spinal ganglia of adult rats in conditions of intracellular recording, that dopamine (1 microM/liter) elicits depolarized responses in 61% of neurons, hyperpolarized in 20% of neurons, and depolarized-hyperpolarized in 19% of neurons. The depolarized responses are associated with the activation of D1 dopamine receptors, and are governed by the shift of cAMP-dependent cation (sodium) channels to the conducting state. The hyperpolarized responses are triggered by the activation of D2 dopamine receptors, which by means of HTP-binding protein convert the potassium channels to the conducting state. The change in the polarization of neurons with the action of dopamine influences their electrical excitability variously.

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