doi: 10.1016/0304-3940(91)90627-6.
Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid
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- PMID: 1837072
- DOI: 10.1016/0304-3940(91)90627-6
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Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid
Neurosci Lett.
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Abstract
This study evaluates the modulation of striatum vulnerability to quinolinic acid (QA) by the nitrostriatal projection. Unilateral lesioning of the substantia nigra with 6-hydroxydopamine markedly reduced the volume of striatal necrosis observed 3 days after local injection of quinolinic acid (150 nmol). This result is consistent with the concept that the nigrostriatal pathway potentiates the vulnerability of striatum to excitotoxic damage.
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