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. 1991 Oct 14;131(2):257-9.
doi: 10.1016/0304-3940(91)90627-6.

Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid

A Buisson  1 , V Pateau, M Plotkine, R G Boulu
Affiliations

Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid

A Buisson et al. Neurosci Lett. .

Abstract

This study evaluates the modulation of striatum vulnerability to quinolinic acid (QA) by the nitrostriatal projection. Unilateral lesioning of the substantia nigra with 6-hydroxydopamine markedly reduced the volume of striatal necrosis observed 3 days after local injection of quinolinic acid (150 nmol). This result is consistent with the concept that the nigrostriatal pathway potentiates the vulnerability of striatum to excitotoxic damage.

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