Review
doi: 10.1016/j.stem.2007.11.010.
Thrombopoietin, HSCs, and the osteoblast niche: holding on loosely, but not letting G0
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- PMID: 18371399
- DOI: 10.1016/j.stem.2007.11.010
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Review
Thrombopoietin, HSCs, and the osteoblast niche: holding on loosely, but not letting G0
Cell Stem Cell.
.
Free article
Abstract
New findings in this issue of Cell Stem Cell by Qian et al. (2007) and Yoshihara et al. (2007) reveal that thrombopoietin modulates hematopoietic stem cell (HSC) cell-cycle progression at the osteoblast surface, linking a single cytokine with a specific postnatal niche cell. These observations indicate that simultaneous stimulation and suspension in a G(0) state are critical for maintenance of the HSC pool.
Comment on
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Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells.Cell Stem Cell. 2007 Dec 13;1(6):671-84. doi: 10.1016/j.stem.2007.10.008. Epub 2007 Nov 20. Cell Stem Cell. 2007. PMID: 18371408
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Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.Cell Stem Cell. 2007 Dec 13;1(6):685-97. doi: 10.1016/j.stem.2007.10.020. Epub 2007 Nov 20. Cell Stem Cell. 2007. PMID: 18371409
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