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Review
. 2007 Dec 13;1(6):599-600.
doi: 10.1016/j.stem.2007.11.010.

Thrombopoietin, HSCs, and the osteoblast niche: holding on loosely, but not letting G0

Stephen G Emerson  1
Affiliations
Free article
Review

Thrombopoietin, HSCs, and the osteoblast niche: holding on loosely, but not letting G0

Stephen G Emerson. Cell Stem Cell. .
Free article

Abstract

New findings in this issue of Cell Stem Cell by Qian et al. (2007) and Yoshihara et al. (2007) reveal that thrombopoietin modulates hematopoietic stem cell (HSC) cell-cycle progression at the osteoblast surface, linking a single cytokine with a specific postnatal niche cell. These observations indicate that simultaneous stimulation and suspension in a G(0) state are critical for maintenance of the HSC pool.

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