Review
doi: 10.1016/j.stem.2008.01.012.
Foxa2: the rise and fall of dopamine neurons
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- PMID: 18371430
- DOI: 10.1016/j.stem.2008.01.012
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Review
Foxa2: the rise and fall of dopamine neurons
Cell Stem Cell.
.
Free article
Abstract
Understanding the development and maintenance of dopamine neurons is essential to establish novel stem cell therapies and animal models of Parkinson's disease. A recent PLoS Biology report (Kittappa et al., 2007) reveals that Foxa2 regulates dopamine neuron generation and differentiation, and that aging foxa2(+/-) mice spontaneously develop Parkinsonism.
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