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Review
. 2008 Feb 7;2(2):110-2.
doi: 10.1016/j.stem.2008.01.012.

Foxa2: the rise and fall of dopamine neurons

Ernest Arenas  1
Affiliations
Free article
Review

Foxa2: the rise and fall of dopamine neurons

Ernest Arenas. Cell Stem Cell. .
Free article

Abstract

Understanding the development and maintenance of dopamine neurons is essential to establish novel stem cell therapies and animal models of Parkinson's disease. A recent PLoS Biology report (Kittappa et al., 2007) reveals that Foxa2 regulates dopamine neuron generation and differentiation, and that aging foxa2(+/-) mice spontaneously develop Parkinsonism.

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