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Editorial
. 2008;10(2):104.
doi: 10.1186/bcr1868. Epub 2008 Mar 14.

Breast cancer surface receptors predict risk for developing brain metastasis and subsequent prognosis

Editorial

Breast cancer surface receptors predict risk for developing brain metastasis and subsequent prognosis

Jai Grewal et al. Breast Cancer Res. 2008.

Abstract

Determining the status of breast cancer surface receptors (estrogen receptor, progesterone receptor, HER2/neu) has become routine in the care of patients with this disease and has proven to be helpful in guiding treatment. For this reason, breast cancer has become a model for molecularly guided therapy in solid tumors. Emerging data support that these receptors are associated with risk for developing brain metastases. Additionally, once brain metastases have occurred these receptors may also correlate with prognosis.

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References

    1. Nam B-H, Kim SY, Han HS, Kwon Y, Lee KS, Kim TH, Ro J. Breast cancer subtypes and survival in patients with brain metastases. Breast Cancer Res. 2008;10:R20. doi: 10.1186/bcr1870. - DOI - PMC - PubMed
    1. Hicks DG, Short SM, Prescott NL, Tarr SM, Coleman KA, Yoder BJ, Crowe JP, Choueiri TK, Dawson AE, Budd GT, Tubbs RR, Casey G, Weil RJ. Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFR. Am J Surg Pathol. 2006;30:1097–1104. - PubMed
    1. Miller KD, Weathers T, Haney LG, Timmerman R, Dickler M, Shen J, Sledge GW., Jr Occult central nervous system involvement in patients with metastatic breast cancer: prevalence, predictive factors and impact on overall survival. Ann Oncol. 2003;14:1072–1077. doi: 10.1093/annonc/mdg300. - DOI - PubMed
    1. Tham YL, Sexton K, Kramer R, Hilsenbeck S, Elledge R. Primary breast cancer phenotypes associated with propensity for central nervous system metastases. Cancer. 2006;107:696–704. doi: 10.1002/cncr.22041. - DOI - PubMed
    1. Weitzen R, Zach L, Kaufman B, Tichler T, Rath P, Pfeffer R. High incidence of brain metastasis (BM) in patients on trastuzumab (H) for advanced breast cancer [abstract] Proc Am Soc Clin Oncol. 2002;21:1936.