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Review
. 2008 Jun 10;314(9):1962-72.
doi: 10.1016/j.yexcr.2008.01.032. Epub 2008 Feb 19.

Aging stem cells, latexin, and longevity

Ying Liang  1 , Gary Van Zant
Affiliations
Review

Aging stem cells, latexin, and longevity

Ying Liang et al. Exp Cell Res. .
No abstract available

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Figures

Figure 1
Figure 1. Biological processes affecting stem cells
The biology of stem cells involves many different cellular processes that take place in order to maintain the appropriate number of HSCs and their functionality during variable environmental conditions throughout life. The stem cell pool is carefully maintained through a balance among proliferation vs quiescence, self-renewal vs differentiation, and the dynamic interplay between extravasation into the blood and lymph (mobilization) vs lodement in a bone marrow niche (homing). Any defect in any of the processes will apply stress on HSCs and lead them to senescence and apoptosis. The compromise of stem cell pool size and their functions will ultimately result in early “aging” involving loss of their normal potential and thus affect longevity. The green arrow indicates cellular processes favoring maintenance of HSC population, whereas brown arrows indicate those factors compromising HSCs. HSCs: hematopoietic stem cells. HPCs: hematopoietic progenitor cells.
Figure 2
Figure 2. Potential roles of latexin in stem cell senescence
Three potential mechanisms may be involved in the regulation of stem cells by latexin: inhibition of carboxypeptidase A (CPA), involvement of intracellular signaling pathways and protein folding. In young stem cells, these mechanisms are well regulated and the biological processes affecting stem cells are balanced. In sum, these result in the homeostasis and normal functionality of stem cell population. As latexin expression increases with age, latexin-associated biological processes are affected, and may contribute to stem cell senescence, and quantitative loss. Age-associated diseases, such as amyloidoses and cancers may also be related to latexin levels in old stem cells. Therefore, latexin represents a good model to address the relationship among stem cell, the rate of aging, the development of age-related diseases, and lifespan.
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