Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Feb;22(2):121-3.
doi: 10.1155/2008/280349.

Start low, go slow, but don't go this way yet

Review

Start low, go slow, but don't go this way yet

Brian Bressler et al. Can J Gastroenterol. 2008 Feb.
No abstract available

PubMed Disclaimer

Figures

Figure 1)
Figure 1)
The metabolism of 6-mercaptopurine (6-MP). DPK Diphosphate kinase; GMPS Guanine monophosphate synthetase; HPRT Hypoxanthine phosphoribosyl transferase; IMPDH Inosine monophosphate dehydrogenase; MPK Monophosphate kinase; TPMT Thiopurine methyltransferase; XO Xanthine oxidase. Reproduced with permission from reference 28

References

    1. Cuffari C. How useful is thiopurine metabolite monitoring in pediatric inflammatory bowel disease? Nat Clin Pract Gastroenterol Hepatol. 2008;5:12–3. - PubMed
    1. Dubinsky MC, Reyes E, Ofman J, Chiou CF, Wade S, Sandborn WJ. A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn’s disease treated with azathioprine or 6-mercaptopurine. Am J Gastroenterol. 2005;100:2239–47. - PubMed
    1. Dubinsky MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: Pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004;2:731–43. - PubMed
    1. Su C, Lichtenstein GR.Treatment of inflammatory bowel disease with azathioprine and 6-mercaptopurine Gastroenterol Clin North Am 200433209–34.viii. - PubMed
    1. Winter J, Walker A, Shapiro D, Gaffney D, Spooner RJ, Mills PR. Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease. Aliment Pharmacol Ther. 2004;20:593–9. - PubMed

MeSH terms

LinkOut - more resources