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Controlled Clinical Trial
. 2009 Apr;91(4 Suppl):1316-8.
doi: 10.1016/j.fertnstert.2008.01.108. Epub 2008 Apr 18.

Nitric oxide metabolite production in the human preimplantation embryo and successful blastocyst formation

Christopher W Lipari  1 , Jairo E Garcia, Yulian Zhao, Kimberly Thrift, Dhananjay Vaidya, Annabelle Rodriguez
Affiliations
Controlled Clinical Trial

Nitric oxide metabolite production in the human preimplantation embryo and successful blastocyst formation

Christopher W Lipari et al. Fertil Steril. 2009 Apr.

Abstract

Eleven patients underwent controlled ovarian hyperstimulation yielding 72 embryos for evaluation. Mean nitric oxide metabolite levels in the insemination media were 2.6 times higher in embryos that progressed to blastocysts by culture day 5 than in those that did not. A comparison of the receiver operating characteristic curves between morphological predictors and nitric oxide metabolite levels revealed a trend toward a stronger association of insemination media nitric oxide metabolite with blastocyst formation.

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Figures

Figure 1
Figure 1
ROC analysis: IM NOx, CD 3 blastomere number and progression to the blastocyst stage by CD 5.
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