Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Controlled Clinical Trial
. 2009 Apr;91(4 Suppl):1316-8.
doi: 10.1016/j.fertnstert.2008.01.108. Epub 2008 Apr 18.

Nitric oxide metabolite production in the human preimplantation embryo and successful blastocyst formation

Christopher W Lipari  1 , Jairo E Garcia, Yulian Zhao, Kimberly Thrift, Dhananjay Vaidya, Annabelle Rodriguez
Affiliations
Controlled Clinical Trial

Nitric oxide metabolite production in the human preimplantation embryo and successful blastocyst formation

Christopher W Lipari et al. Fertil Steril. 2009 Apr.

Abstract

Eleven patients underwent controlled ovarian hyperstimulation yielding 72 embryos for evaluation. Mean nitric oxide metabolite levels in the insemination media were 2.6 times higher in embryos that progressed to blastocysts by culture day 5 than in those that did not. A comparison of the receiver operating characteristic curves between morphological predictors and nitric oxide metabolite levels revealed a trend toward a stronger association of insemination media nitric oxide metabolite with blastocyst formation.

PubMed Disclaimer

Figures

Figure 1
Figure 1
ROC analysis: IM NOx, CD 3 blastomere number and progression to the blastocyst stage by CD 5.
See this image and copyright information in PMC

References

    1. Gardner DK, Lane M. Culture and selection of viable blastocysts: a feasible proposition for human IVF? Hum Reprod Update. 1997;3:367–82. - PubMed
    1. Papanikolaou EG, Camus M, Kolibianakis EM, Van Landuyt L, Van Steirteghem A, Devroey P. In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos. N Engl J Med. 2006;354:1139–46. - PubMed
    1. Scholtes MC, Zeilmaker GH. Blastocyst transfer in day-5 embryo transfer depends primarily on the number of oocytes retrieved and not on age. Fertil Steril. 1998;69:78–83. - PubMed
    1. Milki AA, Hinckley MD, Gebhardt J, Dasig D, Westphal LM, Behr B. Accuracy of day 3 criteria for selecting the best embryos. Fertil Steril. 2002;77:1191–5. - PubMed
    1. Rijnders PM, Jansen CA. The predictive value of day 3 embryo morphology regarding blastocyst formation, pregnancy and implantation rate after day 5 transfer following in-vitro fertilization or intracytoplasmic sperm injection. Hum Reprod. 1998;13:2869–73. - PubMed

Publication types