doi: 10.1016/j.jneuroim.2008.02.001.
Epub 2008 Apr 2.
CTLA-4 and multiple sclerosis: the A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population
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- PMID: 18378005
- DOI: 10.1016/j.jneuroim.2008.02.001
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CTLA-4 and multiple sclerosis: the A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population
J Neuroimmunol.
.
Abstract
Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P<0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.
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