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Review
. 2008 May;24(5):205-7.
doi: 10.1016/j.tig.2008.02.001. Epub 2008 Apr 2.

Solving the shugoshin puzzle

Juraj Gregan  1 , Mario Spirek, Cornelia Rumpf
Affiliations
Review

Solving the shugoshin puzzle

Juraj Gregan et al. Trends Genet. 2008 May.

Abstract

Shugoshin proteins form a complex with protein phosphatase 2A (PP2A) that protects centromeric cohesin from separase-mediated cleavage during yeast meiosis I. Recent work shows that this mechanism is conserved from yeast to mammals. Importantly, a model emerges that explains a long-standing puzzle, namely why the shugoshin-PP2A complex mediates protection of centromeric cohesin from separase cleavage specifically during meiosis I, but not during meiosis II or mitosis.

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Figures

Figure 1
Figure 1
A model of shugoshin–protein phosphatase 2A (PP2A)-mediated protection of centromeric cohesin. Co-localization of cohesin (yellow) with shugoshin–PP2A (purple) at centromeres prevents separase-mediated (green) cleavage of centromeric cohesin during meiosis I (a). Microtubules attached to bi-oriented sister kinetochores (orange) during mitosis and meiosis II (b) produce tension that promotes the relocation of shugoshin–PP2A from the centromeric cohesin sites (c). Sister centromeres and centromere-proximal regions of one homolog are shown. This model is based on the results from the Watanabe and Suja groups [1,2].
See this image and copyright information in PMC

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References

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