doi: 10.1016/j.bmcl.2008.03.039.
Epub 2008 Mar 16.
Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity
Affiliations
- PMID: 18378445
- DOI: 10.1016/j.bmcl.2008.03.039
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Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity
Bioorg Med Chem Lett.
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Abstract
The synthesis of new benzimidazole linked pyrrolobenzodiazepine conjugates is described. Some of these conjugates show significant DNA-binding affinity and, a representative compound 4c shows promising in vitro cytotoxicity against a number of human cancer cell lines.