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Case Reports
. 2008 Jun;52(6):2263-5.
doi: 10.1128/AAC.01568-07. Epub 2008 Mar 31.

Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during candidemia treatment

John D Cleary  1 , Guillermo Garcia-Effron, Stanley W Chapman, David S Perlin
Affiliations
Case Reports

Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during candidemia treatment

John D Cleary et al. Antimicrob Agents Chemother. 2008 Jun.

Abstract

We describe a case of recurring Candida glabrata infection in a 68-year-old African-American female on caspofungin therapy. The initial isolate was susceptible, but isolates recovered during following relapses were not. All isolates were clonal, and high-MIC strains contained a mutation in the highly conserved hot spot 1 region of Fks1p.

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Figures

FIG. 1.
FIG. 1.
(A) Alignment of C. glabrata fks1 gene sequences showing the mutation in hot spot 1 (square). Dots represent the same nt as those in the reference strain (90030). (B) Alignment of C. glabrata Fks1p sequences showing the amino acid change. The square shows C. glabrata Fks1p hot spot 1.
See this image and copyright information in PMC

References

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